DR. YUE, Patrick Ying Kit (余英傑)

Lecturer
EDUCATION

Ph.D., B.Sc. (Hons.) (HKBU)

CURRENT RESEARCH INTERESTS

  • Pharmacological and biomedical effects of Chinese medicines and natural products
  • Angiomodulation study
  • Research and development of high throughput screening platform for cell motility study

RESEARCH PROJECTS

  1. Tumoricidal effects of Panax Ginseng on nasopharyngeal carcinoma. (Co-I: Prof. Ricky NS Wong). Source: FRG/ HKBU.
  2. The anti-angiogenic activities of indirubin derivatives (indirubin-3’-oxime and E804)(Co-I: Dr. Kelvin SY Leung/ Shi Jue). Source: FRG/ HKBU.
  3. Molecular Biology / Introduction to Biotechnology – Multimedia Education Packages for Studying Genetic Modified Organisms. (Co-I: Prof. JH Zhang/ Ricky NS Wong/ NK Mak/ Chris KC Wong/ YL Xia). Source: TDG/ HKBU.

SELECTED PUBLICATIONS

Book

  1. PYK Yue* and RNS Wong. The Ginsenosides: Yin and Yang in Angiogenesis. LAP LAMBERT Academic Publishing AG & Co. KG. 2009.

Book Chapters

  1. PYK Yue*, Y Huang, RNS Wong. Ginsenoside Rg3 and Rh2: the anti-cancer and anti-angiogenic saponins from ginseng. “Anti-Angiogenesis-Drug Discovery and Development”. volume1, issue 1, p34-57. Bentham Science Publishers. 2010.
  2. PYK Yue*, YK Cheng, NK Mak, KW Leung, AST Leung, TP Fan, RNS Wong. Chapter 21 Ginseng and angiogenesis. Angiogenesis: Basic Science and Clinical Application. p.351-66. Transworld Research Network. 2007

Reviews

  1. Yue PY, Wong YY, Chan TY, Law CK, Tsoi YK, Leung KS. Review of Biological and Pharmacological Activities of the Endemic Taiwanese Bitter Medicinal Mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (Higher Basidiomycetes). Int J Med Mushrooms. 2012;14(3):241-56.
  2. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan DT, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007; 15;2:6. Review. (Top accessed journal)
  3. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, Ng TB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007; 14(12):1371-80. Review.
  4. Fan TP, Yeh JC, Leung KW, Yue PY, Wong RN. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006; 27(6):297-309. Review.

Research Articles

  1. Chan LS, Yue PY, Kok TW, Keung MH, Mak NK, Wong RN. Ginsenoside-Rb1 Promotes Adipogenesis Through Regulation of PPARγ and MicroRNA-27b.Horm Metab Res. 2012 In press.
  2. Kwok HH, Yue PY, Mak NK, Wong RN. Ginsenoside Rb(1) induces type I collagen expression through peroxisome proliferator-activated receptor-delta. Biochem Pharmacol. 2012 Aug 15;84(4):532-9.
  3. Kwok HH, Guo GL, Lau JK, Cheng YK, Wang JR, Jiang ZH, Keung MH, Mak NK, Yue PY, Wong RN. Stereoisomers ginsenosides-20(S)-Rg(3) and -20(R)-Rg(3) differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma. Biochem Pharmacol. 2012; 83(7):893-902.
  4. Chan YK, Kwok HH, Chan LS, Leung KS, Shi J, Mak NK, Wong RN, Yue PY*. An indirubin derivative, E804, exhibits potent angiosuppressive activity. Chan YK, Biochem Pharmacol. 2012; 83(5):598-607.
  5. Poon PY, Kwok HH, Yue PY, Yang MS, Mak NK, Wong CK, Wong RN. Cytoprotective Effect of 20(S)-Rg3 on Benzo(a)pyrene-induced DNA Damage. Drug Metab Dispos. 2012; 40(1):120-9.
  6. Chan LY, Kwok HH, Chan RW, Peiris MJ, Mak NK, Wong RN, Chan MC, Yue PY*. Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J Ethnopharmacol. 2011; 137(3):1542-6.
  7. Yue PY, Leung EP, Mak NK, Wong RN. A simplified method for quantifying cell migration/wound healing in 96-well plates. J Biomol Screen. 2010; 15(4):427-33.
  8. Kwok HH, Ng WY, Yang MS, Mak NK, Wong RN, Yue PY*. The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status. Free Radic Biol Med. 2010; 48(3):437-45.
  9. Chan LS, Yue PY, Mak NK, Wong RN. Role of MicroRNA-214 in ginsenoside-Rg1-induced angiogenesis. Eur J Pharm Sci. 2009; 38(4):370-7.
  10. CC Lau, WY Ha, PYK Yue, SH Chui, AKK Chui, RNS Wong. A high throughput detection method for hepatitis B virus mutations in the Chinese population. Hong Kong Medical Journal. 2008; 14(5): 4-7.
  11. Lau CC, Yue PY, Chui SH, Chui AK, Yam WC, Wong RN. Detection of single nucleotide polymorphisms in hepatitis B virus precore/basal core promoter region by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2007; 366(1):93-5.
  12. Lam HW, Lin HC, Lao SC, Gao JL, Hong SJ, Leong CW, Yue PY, Kwan YW, Leung AY, Wang YT, Lee SM. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. J Cell Biochem. 2008; 103(1):195-211.
  13. P Yue, DYL Wong, P.K. Wu, PY Leung, NK Mak, HW Yeung, L. Liu, ZW Cai, ZH Jiang, TPD Fan, Ricky N.S. Wong. The angiosuppressive effects of ginsenoside-Rg3. Biochem Pharmacol. 2006; 72(4):437-45.
  14. WY Ha, XJ Li, PYK Yue, Daisy YL Wong, Kevin KM Yue, WS Chung, L. Zhao, PY Leung, L. Liu, Ricky N.S. Wong. Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1β stimulation. Inflamm Res. 2006; 55(7):293-9.
  15. Li XJ, Yue PY, Ha WY, Wong DY, Tin MM, Wang PX, Wong RN, Liu L. Effects of the alkaloid sinomenine on gene expression of the IL-1b-activated human synovial sarcoma cells. Life Sci. 2006; 79(7):665-73.
  16. Ha WY, Lau CC, Yue PY, Hung KK, Chan K, Chui SH, Chui AK, Yam WC, Wong RN. Simultaneous detection of precore/basal core promoter mutations in Hepatitis B virus using arrayed primer extension. Mol Diagn Ther. 2006; 10(2):125-34.
  17. Ha WY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PY, Ngai SM, Tsai SN, Wong RN. Involvement of PKC and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Intl J Biochem Cell Biol. 2006; 38(8): 1393-1401.
  18. Zhao HY, Wong RNS, Fang KT, Yue PYK. Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs Chemometrics and Intelligent Laboratory Systems. (2006); 82:31-36.
  19. Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro. Angiogenesis. 2005; 8(3):205-16.
  20. Liu L, Han L, Wong DY, Yue PY, Ha WY, Hu YH, Wang PX, Wong RN. Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells. Br J Nutr. 2005; 93(1), 21-29.
  21. Liu MJ, Yue PY, Wang Z, Wong RN. Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Lett. 2005; 224(2), 229-241.
  22. Kok TW, Yue PY, Mak NK, Fan TP, Liu L, Wong RN. The anti-angiogenic effect of sinomenine. Angiogenesis. 2005; 8(1):3-12.
  23. Zhao HY, Yue PY, Fang KT. Identification of differentially expressed genes with Multivariate Outlier Analysis. J Biopharm Stat. 2004; 14(3):629-46.

CONTACT DETAILS

Email: patrick@hkbu.edu.hk
Office: T1116
Office Tel: (+852) 3411 5832