DR. YUE, Patrick Ying Kit (余英傑)

  • Lecturer I
  • Admission Officer
  • EDUCATION

    Ph.D., B.Sc. (Hons.) (HKBU)

    AWARDS AND RECOGNITIONS

    • First class award. 2014 Ministry of Education Higher Education Outstanding Scientific Research Output Awards (Science and Technology) State Natural Science.
    • Long Service Award (15-years). 2015 HKBU.
    • Certificate of Appreciation. 2015 Faculty of Science/ HKBU.
    • Long Service Award (10-years). 2010 HKBU.

    PATENTS

    • United State Patent (US 9,533,301 B2) 2017. Title of invention: Mechanical cell wounder device and related method.
    • China Patent (CN200710127846) 2007. Title of invention: Mechanical cell wounder device and related method.

    COMPANY HOLDER

    • R&P Technology Limited. .

    SERVICE

    • DSE. Hong Kong Examinations and Assessment Authority
    • Local TV program – 學是學非, 東張西望, 歎得好健康, 都市閒情. 2014 – Date.

    INTERNATIONAL/LOCAL COMPETITION ADJUDICATOR

    • BIOMOD Jamboree. International Bio-Molecular Design Competition. Wyss Institute for Biologically Inspired Engineering, Harvard University. 2012 – Date.
    • The 20th Hong Kong Youth Science and Technology Innovation Competition
    • The 69th Intel International Science and Engineering Fair (Intel ISEF) – Hong Kong Regional Final
    • 51st Joint School Science Exhibition – Proposal Competition

    STEM, GIFTED EDUCATION and COMMUNITY OUTREACH

    • Theme-based school talk – Serve target: Local Schools
    • Summer workshop – Serve target: Local Schools
    • STEM education – Serve target: Local Schools and The Hong Kong Academy for Gifted Education

    FUNDED TEACHING PROJECTS

    • Developing Online Courses/Blended Learning Initiatives with FutureLearn. 2017-2018
    • Course Enhancement Funds. UGC T&L Project on Information Literacy: Enhancing information literacy (IL) in Hong Kong higher education. 2nd semester, 2016-2017
    • Course Enhancement Funds. UGC T&L Project on Information Literacy: Enhancing information literacy (IL) in Hong Kong higher education. 1st semester 2016-2017
    • Teaching Development Grant. Project title: Molecular biology/ Introduction to biotechnology – Multimedia education packages for studying genetic modified (GM) organisms (GM-foods). 2010

    CURRENT RESEARCH INTERESTS

    • Pharmacological and biomedical effects of Chinese medicines and natural products
    • Angiomodulation study
    • Research and development of high throughput screening platform for cell motility study

    RESEARCH PROJECTS

    1. Tumoricidal effects of Panax Ginseng on nasopharyngeal carcinoma. (Co-I: Prof. Ricky NS Wong). Source: FRG/ HKBU.
    2. The anti-angiogenic activities of indirubin derivatives (indirubin-3’-oxime and E804)(Co-I: Dr. Kelvin SY Leung/ Shi Jue). Source: FRG/ HKBU.
    3. Molecular Biology / Introduction to Biotechnology – Multimedia Education Packages for Studying Genetic Modified Organisms. (Co-I: Prof. JH Zhang/ Ricky NS Wong/ NK Mak/ Chris KC Wong/ YL Xia). Source: TDG/ HKBU.

    SELECTED PUBLICATIONS

    Book

    1. PYK Yue* and RNS Wong. The Ginsenosides: Yin and Yang in Angiogenesis. LAP LAMBERT Academic Publishing AG & Co. KG. 2009.

    Book Chapters

    1. PYK Yue*, Y Huang, RNS Wong. Ginsenoside Rg3 and Rh2: the anti-cancer and anti-angiogenic saponins from ginseng. “Anti-Angiogenesis-Drug Discovery and Development”. volume1, issue 1, p34-57. Bentham Science Publishers. 2010.
    2. PYK Yue*, YK Cheng, NK Mak, KW Leung, AST Leung, TP Fan, RNS Wong. Chapter 21 Ginseng and angiogenesis. Angiogenesis: Basic Science and Clinical Application. p.351-66. Transworld Research Network. 2007

    Reviews

    1. Yue PY*, Leung HM, Li AJ, Chan TN, Lum TS, Chung YL, Sung YH, Wong MH, Leung KS, Zeng EY. Angiosuppressive properties of marine-derived compounds-a mini review. Environ Sci Pollut Res Int. 2015 Oct 31.
    2. Yue PY*, Wong YY, Wong YK, Tsoi YK, Leung SY. Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea. BMC Chin Med. 2013;8(1):21.
    3. Yue PY, Wong YY, Chan TY, Law CK, Tsoi YK, Leung KS. Review of Biological and Pharmacological Activities of the Endemic Taiwanese Bitter Medicinal Mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (Higher Basidiomycetes). Int J Med Mushrooms. 2012;14(3):241-56.
    4. Yue PY, Mak NK, Cheng YK, Leung KW, Ng TB, Fan DT, Yeung HW, Wong RN. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med. 2007; 15;2:6. Review. (Top accessed journal)
    5. Leung KW, Yung KK, Mak NK, Yue PY, Luo HB, Cheng YK, Fan TP, Yeung HW, Ng TB, Wong RN. Angiomodulatory and neurological effects of ginsenosides. Curr Med Chem. 2007; 14(12):1371-80. Review.
    6. Fan TP, Yeh JC, Leung KW, Yue PY, Wong RN. Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci. 2006; 27(6):297-309. Review.

    Research Articles (*-corresponding author #-equal contribution)

    1. Tang MKS, Yue PY, Ip PP, Huang RL, Lai HC, Cheung ANY, Tse KY, Ngan HYS, Wong AST. Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface. Nat Commun. 2018;9(1):2270. (Impact Factor – 11.05)
    2. Sung WN, Kwok HH, Rhee MH, Yue PY, Wong RN. Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor. J Ginseng Res. 2017;41(4):477-486.
    3. Yue PY, Ha WY, Lau CC, Cheung FM, Lee AW, Ng WT, Ngan RK, Yau CC, Kwong DL, Lung HL, Mak NK, Lung ML, Wong RN. MicroRNA profiling study reveals miR-150 in association with metastasis in nasopharyngeal carcinoma. Sci Rep. 2017;7(1):12012.
    4. Kwok HH, Poon PY, Mak KH, Zhang LY, Liu P, Zhang H, Mak NK, Yue PY, Wong RN. Role of G3BP1 in glucocorticoid receptor-mediated microRNA-15b and microRNA-23a biogenesis in endothelial cells. Cell Mol Life Sci. 2017;74(19):3613-3630.
    5. Poon PY, Yue PY, Wong RN. A Device for Performing Cell Migration/Wound Healing in a 96-Well Plate. J Vis Exp. 2017 Mar 7;(121)
    6. Chan JT, Leung HM, Yue PY, Au CK, Wong YK, Cheung KC, Li WC, Yung KK. Combined effects of land reclamation, channel dredging upon the bioavailable concentration of polycyclic aromatic hydrocarbons (PAHs) in Victoria Harbour sediment, Hong Kong. Mar Pollut Bull. 2017;114(1):587-91
    7. Keung MH, Chan LS, Kwok HH, Wong RN, Yue PY*. Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression. J Ginseng Res. 2016;40(2):151-9.
    8. Sun H, Yue PY, Wang SR, Huo L, Zhao Y, Xie S, Kringelum JV, Lund O, Taboureau O, Zhou J, Wong RN, Fang WS. Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates. Med Chem. 2016;12(8):775-85.
    9. Li AJ, Schmitz OJ, Stephan S, Lenzen C, Yue PY, Li K, Li H, Leung KS. Photocatalytic transformation of acesulfame: Transformation products identification and embryotoxicity study. Water Res. 2016;89:68-75.
    10. Chan YK, Zhang HM, Liu P, Tsao GS, Lung ML, Mak NK, Wong RN, Yue PY*. Proteomic analysis of Exosomes from Nasopharyngeal Carcinoma Cell identifies Intercellular Transfer of Angiogenic Proteins. Int J Cancer. 2015;137(8):1830-41.
    11. Kwok HH, Chan LS, Poon PY, Yue PY, Wong RN. Ginsenoside-Rg1 induces angiogenesis by the inverse regulation of MET tyrosine kinase receptor expression through miR-23a. Toxicol Appl Pharmacol. 2015;287(3):276-83.
    12. Wang L, Lu AP, Yu ZL, Wong RN, Bian ZX, Kwok HH, Yue PY, Zhou LM, Chen H, Xu M, Yang Z. The Melanogenesis-Inhibitory Effect and the Percutaneous Formulation of Ginsenoside Rb1. AAPS PharmSciTech. 2014;15(5):1252-62.
    13. Mok CK, Kang SS, Chan RW, Yue PY, Mak NK, Poon LL, Wong RN, Peiris JS, Chan MC. Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells. Antiviral Res. 2014;106:95-104.
    14. Law KM, Kwok HH, Poon PY, Lau CC, Jiang ZH, Tai WC, Hsiao WW, Mak NK, Yue YK*, Wong RN*. Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor. BMC Chin Med. 2014; 9:11.
    15. Chan LS#, Yue PY#, Wong YY, Wong RN. MicroRNA-15b contributes to ginsenoside-Rg1-induced angiogenesis through increased expression of VEGFR-2. Biochem Pharmacol. 2013; 86(3):392-400.
    16. Chan HH, Law YK, Chu MT, Yue KK, Jiang ZH, Lau CW, Huang Y, Chan SW, Yue PY, Wong RN. Ginseng Extracts Restore High-Glucose Induced Vascular Dysfunctions by Altering Triglyceride Metabolism and Downregulation of Atherosclerosis-Related Genes. Evid Based Complementary Alternat Med. 2013; 2013:797310.
    17. Wong VK, Zhang MM, Zhou H, Lam KY, Chan PL, Law CK, Yue PY, Liu L. Saikosaponin-d Enhances the Anticancer Potency of TNF-α via Overcoming Its Undesirable Response of Activating NF-Kappa B Signalling in Cancer Cells. Evid Based Complement Alternat Med. 2013; 2013:745295.
    18. Chan YK, Kwok HH, Chan LS, Leung KS, Shi J, Mak NK, Wong RN, Yue PY*. An indirubin derivative, E804, exhibits potent angiosuppressive activity. Chan YK, Biochem Pharmacol. 2012; 83(5):598-607.
    19. Chan LY, Kwok HH, Chan RW, Peiris MJ, Mak NK, Wong RN, Chan MC, Yue PY*. Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J Ethnopharmacol. 2011; 137(3):1542-6.
    20. Chan LS#, Yue PY#, Kok TW, Keung MH, Mak NK, Wong RN. Ginsenoside-Rb1 Promotes Adipogenesis Through Regulation of PPARγ and MicroRNA-27b. Horm Metab Res. 2012;44(11):819-24.
    21. Kwok HH, Yue PY, Mak NK, Wong RN. Ginsenoside Rb(1) induces type I collagen expression through peroxisome proliferator-activated receptor-delta. Biochem Pharmacol. 2012 Aug 15;84(4):532-9.
    22. Kwok HH, Guo GL, Lau JK, Cheng YK, Wang JR, Jiang ZH, Keung MH, Mak NK, Yue PY, Wong RN. Stereoisomers ginsenosides-20(S)-Rg(3) and -20(R)-Rg(3) differentially induce angiogenesis through peroxisome proliferator-activated receptor-gamma. Biochem Pharmacol. 2012; 83(7):893-902.
    23. Poon PY, Kwok HH, Yue PY, Yang MS, Mak NK, Wong CK, Wong RN. Cytoprotective Effect of 20(S)-Rg3 on Benzo(a)pyrene-induced DNA Damage. Drug Metab Dispos. 2012; 40(1):120-9.
    24. Chan LY, Kwok HH, Chan RW, Peiris MJ, Mak NK, Wong RN, Chan MC, Yue PY*. Dual functions of ginsenosides in protecting human endothelial cells against influenza H9N2-induced inflammation and apoptosis. J Ethnopharmacol. 2011; 137(3):1542-6.
    25. Yue PY, Leung EP, Mak NK, Wong RN. A simplified method for quantifying cell migration/wound healing in 96-well plates. J Biomol Screen. 2010; 15(4):427-33.
    26. Kwok HH, Ng WY, Yang MS, Mak NK, Wong RN, Yue PY*. The ginsenoside protopanaxatriol protects endothelial cells from hydrogen peroxide-induced cell injury and cell death by modulating intracellular redox status. Free Radic Biol Med. 2010; 48(3):437-45.
    27. Chan LS, Yue PY, Mak NK, Wong RN. Role of MicroRNA-214 in ginsenoside-Rg1-induced angiogenesis. Eur J Pharm Sci. 2009; 38(4):370-7.
    28. CC Lau, WY Ha, PYK Yue, SH Chui, AKK Chui, RNS Wong. A high throughput detection method for hepatitis B virus mutations in the Chinese population. Hong Kong Medical Journal. 2008; 14(5): 4-7.
    29. Lau CC, Yue PY, Chui SH, Chui AK, Yam WC, Wong RN. Detection of single nucleotide polymorphisms in hepatitis B virus precore/basal core promoter region by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2007<; 366(1):93-5.
    30. Lam HW, Lin HC, Lao SC, Gao JL, Hong SJ, Leong CW, Yue PY, Kwan YW, Leung AY, Wang YT, Lee SM. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo. J Cell Biochem. 2008; 103(1):195-211.
    31. P Yue, DYL Wong, P.K. Wu, PY Leung, NK Mak, HW Yeung, L. Liu, ZW Cai, ZH Jiang, TPD Fan, Ricky N.S. Wong. The angiosuppressive effects of ginsenoside-Rg3. Biochem Pharmacol. 2006; 72(4):437-45.
    32. WY Ha, XJ Li, PYK Yue, Daisy YL Wong, Kevin KM Yue, WS Chung, L. Zhao, PY Leung, L. Liu, Ricky N.S. Wong. Gene expression profiling of human synovial sarcoma cell line (Hs701.T) in response to IL-1β stimulation. Inflamm Res. 2006; 55(7):293-9.
    33. Li XJ, Yue PY, Ha WY, Wong DY, Tin MM, Wang PX, Wong RN, Liu L. Effects of the alkaloid sinomenine on gene expression of the IL-1b-activated human synovial sarcoma cells. Life Sci. 2006; 79(7):665-73.
    34. Ha WY, Lau CC, Yue PY, Hung KK, Chan K, Chui SH, Chui AK, Yam WC, Wong RN. Simultaneous detection of precore/basal core promoter mutations in Hepatitis B virus using arrayed primer extension. Mol Diagn Ther. 2006; 10(2):125-34.
    35. Ha WY, Wu PK, Kok TW, Leung KW, Mak NK, Yue PY, Ngai SM, Tsai SN, Wong RN. Involvement of PKC and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma. Intl J Biochem Cell Biol. 2006; 38(8): 1393-1401.
    36. Zhao HY, Wong RNS, Fang KT, Yue PYK. Use of three-color cDNA microarray experiments to assess the therapeutic and side effect of drugs Chemometrics and Intelligent Laboratory Systems. (2006); 82:31-36.
    37. Yue PY, Wong DY, Ha WY, Fung MC, Mak NK, Yeung HW, Leung HW, Chan K, Liu L, Fan TP, Wong RN. Elucidation of mechanisms underlying the angiogenic effects of ginsenoside Rg1 in vivo and in vitro. Angiogenesis. 2005; 8(3):205-16.
    38. Liu L, Han L, Wong DY, Yue PY, Ha WY, Hu YH, Wang PX, Wong RN. Effects of Si-Jun-Zi decoction polysaccharides on cell migration and gene expression in wounded rat intestinal epithelial cells. Br J Nutr. 2005; 93(1), 21-29.
    39. Liu MJ, Yue PY, Wang Z, Wong RN. Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria. Cancer Lett. 2005; 224(2), 229-241.
    40. Kok TW, Yue PY, Mak NK, Fan TP, Liu L, Wong RN. The anti-angiogenic effect of sinomenine. Angiogenesis. 2005; 8(1):3-12.
    41. Zhao HY, Yue PY, Fang KT. Identification of differentially expressed genes with Multivariate Outlier Analysis. J Biopharm Stat. 2004; 14(3):629-46.

    CONTACT DETAILS

    Email: patrick@hkbu.edu.hk
    Office: T1116
    Office Tel: (+852) 3411 5832