DR. ZHANG, Shoudong (张守栋)

Research Assistant Professor

Ph.D. (University of Vienna)
M.Sc. (Nanjing Agricultural University)


    1. Alternative splicing of pre-mRNAs under stresses

    Alternative splicing of pre-mRNA is a regulated process of gene expression which results in a single gene coding for multiple proteins. Therefore, alternative splicing may have a diversity of physiological roles to plant growth, development and plant adaptation to environmental Stresses. Using a lsm5/sad1 weak allele, we have found that mis-alternative splicing will severely affect plant growth, development and adaptation to salt stress (Cui, Zhang, et al. 2014). We will further use the weak allele to investigate alternative splicing roles of pre-mRNAs in plant adaptation to other stresses and related mechanism. Recent CO-IP experiments with LSM5-3flag, we found that ABA treatment may greatly promote some stress-related proteins interacted with the component of spliceosome. So, we will focus on ABA mediated alternative splicing, and these transcript isoforms functions in drought stresses.

    2. Mobile macromolecules and their physiological functions under stress environments

    Long-/short-macromolecular movement via plasmodesmata and phloem sieve elements greatly contribute to plant growth, development, and adaptation to stress environments. Current sequencing technics greatly advance our knowledge about mobile macromolecular abundance. To better serve the plant biologist committee, we first build up a mobile molecular database (Guan, et al, 2017, NAR in revision). Based on our previous studies on mobile macromolecules (Winter, et al. 2007) and systemic small RNAs (Zhang, et al. 2009), we further study mobile macromolecular physiological roles in plant adaptation to environmental stresses.

    3. Environmental epigenetics

    DNA methylation/demethylation, histone modification and histone variants depositions cause chromatin relaxation/condensation, and thus affect transcriptional factors binding to right places to initiate transcription (gene expression). Environmental effects on the supplies of methyl group, acetyl-coA, etc. or the abundance of histone variants may finally determine chromatin status, and thus regulate related gene expression. We ever cloned two allele of histone deacetylase 6 (HDA6), they have obvious epigenetic modification patterns (even opposite patterns) on transgenic promoters and some endogenous loci (Zhang, et al. 2015). Recently we found that HDA6 may affect H2A.Z deposition, and connect temperature stresses and epigenetic modification well. We will further investigate HDA6 functions on H2A.Z recruitment and deposition, especially different allele adaptation to temperature fluctuations.


  1. ShouDong Zhang, Huoming Zhang, Yiji Xia, Liming Xiong. The caseinolytic protease complex component CLPC1 in Arabidopsis maintains proteome and RNA homeostasis in chloroplasts. (in revision)
  2. Daogang Guan, Bin Yan, Jingmin Hua, Christoph Thieme, Hailong Zhu, Zhongying Zhao, Friedrich Kragler*, Yiji Xia*, Shoudong Zhang*. (2017) PlaMoM: A comprehensive database compiles plant mobile macromolecules. NUCLEI ACID RESEARCH (NAR) (in revision)
  3. Shoudong Zhang, Xiangqiang Zhan, Xiaoming Xu, Peng Cui, Jian-Kang Zhu2,4, Yiji Xia and Liming Xiong (2015)Two domain-disrupted hda6 alleles have opposite epigenetic effects on transgenes and some endogenous targets. Scientific Reports 5:17832 (IF:5.578)
  4. Peng Cui1#, Shoudong Zhang1#, Feng Ding, ShahjahanAli and Liming Xiong (2014) Dynamic Regulation of Genome-wide Alternative Splicing and Stress Tolerance by the Sm-like Protein SAD1 in Arabidopsis. Genome Biology, 15:R1 (#, co-first author),(citation:17) (IF:10.8)
  5. Shoudong Zhang, Li Sun and Friedrich Kragler (2009) The Phloem-Delivered RNA Pool Contains Small Noncoding RNAs and Interferes with Translation. Plant Physiology 150:378-387 (citation:98) (IF:8.03)
  6. Feng Ding, Peng Cui, Zhenyu Wang, Shoudong Zhang, Shahjahan Ali and Liming Xiong (2014) Genome-wide analysis of alternative splicing of pre-mRNA under salt stress in Arabidopsis. BMC Genomics. 15:431 (citation:26) (IF:3.986)
  7. Tao Chen, Peng Cui,, Hao Chen, Shahjahan Ali, Shoudong Zhang, Liming Xiong (2013) A KH-Domain RNA-Binding Protein Interacts with FIERY2/CTD Phosphatase-Like 1 and Splicing Factors and Is Important for Pre-mRNA Splicing in Arabidopsis. Plos Genetics 9(10): e1003875. (citation:16) (IF:7.528)
  8. Na You, Gabriel Murillo, Xiaoquan Su, Xiaowei Zeng, Jian Xu, Kang Ning, Shoudong Zhang, Jiankang Zhu, and Xinping Cui (2012) SNP calling using genotype model selection on high-throughput sequencing data. Bioinformatics. 28(5): 643-650 (citation: 21) (IF:4.981)
  9. Zhihuan Gao, Hai-Liang Liu, Lucia Daxinger, Olga Pontes, Xinjian He, Weiqiang Qian, Huixin Lin, Mingtang Xie, Zdravko J. Lorkovic, Shoudong Zhang, Daisuke Miki, Xianqiang Zhan, Dominique Pontier, Thierry Lagrange, Hailing Jin, Antonius J. Matzke, Marjori Matzke, Craig S. Pikaard, and Jian-Kang Zhu, (2010) An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation. Nature. May 6; 465(7294): 106–109 (citation: 140) (IF:41.456)
  10. Nikola Winter, Gregor Kollwig, Shoudong Zhang and Friedrich Kragler (2007) MPB2C, a Microtubule-Associated Protein, Regulates Non-Cell-Autonomy of the Homeodomain Protein KNOTTED. The Plant Cell 19:3001-3018 (citation: 46) (IF:10.529)


Email: szhang@hkbu.edu.hk
Office: T702
Office Tel: (+852) 3411 5834