PROF. MAK, Nai Ki (麥乃岐)

Professor
EDUCATIONPh.D. (Australian National University)
B.Sc. (Hons.) (CUHK)
CURRENT RESEARCH INTERESTS

  • Targeting Epstein-Barr virus in nasopharyngeal carcinoma
  • Wnt/β-catenin signaling in cancer
  • Cancer stem cells
  • miRNAs in cancer

RESEARCH PROJECTS

  • Targeting Epstein-Barr virus in nasopharyngeal carcinoma: from mechanistic study to novel therapeutic development (Collaborative Research Fund, UGC; 2019 – 2022)
  • Targeting of EBNA1 viral protein as a therapeutic approach for EBV-associated tumour with tailor responsive optical imaging (HKBU; 2017 – 2020)
  • Therapeutic targeting of Nasopharyngeal carcinoma (Areas of Excellence Scheme, UGC, 2016 – 2018)

SELECTED PUBLICATIONS

  1. Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreströmg, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung Wong. (Dec 2019) Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function. PNAS, vol. 116 (issue 52).   pnas.org/cgi/doi/10.1073/pnas.1915372116.
  2. Luo Chen, Lai Sheung Chan, Hong Lok Lung, Timothy Tak Chun Yip, Roger Kai Cheong Ngan, Jonathan Woon Chung Wong, Kwok Wai Lo, Wai Tong Ng, Anne Wing Mui Lee, George Sai Wah Tsao, Maria Li Lung, Nai Ki Mak. (2019) Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/ Wnt inhibitory factor 1 (WIF1) axis. Phytomedicine. https://doi.org/10.1016/j.phymed.2019.153058.
  3. NK Mak, H.L. Lung, K.F. Hui, and A.S.K. Chiang. (2019) Translational studies: Drug candidates and preclinical testing.  In “Nasopharyngeal carcinoma: From Etiology to Clinical Practice”.  Edited by Anne W.M. Lee, Maria Li Lung and Wai Tong Ng.  Academic Press.  p109 – 127.  ISBN:9780128149362.
  4. Lai-Sheung CHAN, On-Ying MAN, Hoi-Hin KWOK, Luo CHEN, King-Chi CHAN, Hong-Lok LUNG, Roger Kai-Cheong NGAN, Ricky Ngok-Shun WONG, Kwok-Wai LO, Anne Wing-Mui LEE, George Sai-Wah TSAO, Michael Kahn, Maria Li LUNG and Nai-Ki MAK. (2018) The Wnt modulator ICG-001 mediates the inhibition of nasopharyngeal carcinoma cell migration in vitro via the miR-150/CD44 axis. International Journal of Oncology, DOI: 10.3892/ijo.2018.4664.
  5. Lijun Jiang, Chen Xie, Hong Lok Lung, Kwok Wai Lo, Ga-Lai Law, Nai-Ki Mak, and Ka-Leung Wong. (2018) EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics, 8(19), 5307–5319. doi: 10.7150/thno.26823.
  6. Lijun Jiang, Rongfeng Lan, Tao Huang, Chi-Fai Chan, Hongguang Li, Sam Lear, Jingyi Zong, Wing-Yan Wong, Magnolia Muk-Lan Lee, Brandon Dow Chan, Wai-Lun Chan, Wai-Sum Lo, *Nai-Ki Mak, Maria Li Lung, Hong Lok Lung, Sai Wah Tsao, Graham S. Taylor, Zhao-Xiang Bian, William C. S. Tai, Ga-Lai Law, Wing-Tak Wong, Steven L. Cobb, and Ka-Leung Wong. (2017). EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein–Barr virus. Nature Biomedical Engineering.  DOI: 10.1038/s41551 – 017-0042.
  7. Kwok HH, Poon PY, Mak KH, Zhang LY, Liu P, Zhang H, Mak NK, Yue PY, *Wong RN. (2017) Role of G3BP1 in glucocorticoid receptor-mediated microRNA-15b and microRNA-23a biogenesis in endothelial cells.  Cell Mol Life Sci. 2017. doi: 10.1007/s00018-017-2540-y.
  8. Mok CK, Kang SS, Chan RW, Yue PY, Mak NK, Poon LL, Wong RN, Peiris JS, Chan MC. (2014) Anti-inflammatory and antiviral effects of indirubin derivatives in influenza A (H5N1) virus infected primary human peripheral blood-derived macrophages and alveolar epithelial cells. Antiviral Res. doi: 10.1016/j.antiviral.2014.03.019.
  9. Chan KC, Ting CM, Chan PS, Lo MC, Lo KW, Curry JE, Smyth T, Lee AWM, Ng WT, Tsao GSW, Wong RNS, Lung ML and Mak NK. (2013) A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation. Molecular Cancer. 12(1), 128. https://doi.org/10.1186/1476-4598-12-128.

CONTACT DETAILS

Email: nkmak@hkbu.edu.hk
Office: RRS 818
Office Tel: (+852) 3411 7059