PROF. YUNG, Ken Kin Lam (翁建霖)

Professor and Associate Head
EDUCATIOND.Phil. (Oxford)
M.Phil. (HKU)
B.Sc. (Hons.) (HKBU)
CURRENT RESEARCH INTERESTS

  • Neurobiology of receptors and neurological diseases
  • Neurotoxicology
  • Neuropharmacology

SELECTED PUBLICATIONS

  1. Fu P, Bai L, Cai Z, Li R, Yung KKL (2020) Fine particulate matter aggravates intestinal and brain injury and affects bacterial community structure of intestine and feces in Alzheimer’s disease transgenic mice. Ecotoxicol. Environ. Saf. 192, 110325.
  2. Fu P, Gao M, Yung KKL (2020) Association of intestinal disorders with Parkinson’s Disease and Alzheimer’s Disease: A systematic review and Meta-analysis. ACS Chem. Neurosci. 11, 395–405.
  3. Fu P, Guo X, Cheung FMH, Yung KKL (2019) The association between PM2.5 exposure and neurological disorders: A systematic review and meta-analysis. Sci. Total Environ. 655, 1240–1248.
  4. Zhang Z, Zhang S, Fu P, Zhang Z, Lin K, Ko JKS, Yung KKL (2019) Roles of Glutamate Receptors in Parkinson’s Disease. Int. J. Mol. Sci. 20, 4391.
  5. Lin K, Liu B, Lim SL, Fu X, Sze SCW, Yung KKL, Zhang S (2019) 20(S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway. J. Ginseng Res. 44, 475–482.
  6. Zhang S, Sun P, Lin K, Chan FHL, Gao Q, Lau WF, Roy VAL, Zhang H, Lai KWC, Huang Z, Yung KKL (2019) Extracellular Nanomatrix‐Induced Self‐Organization of Neural Stem Cells into Miniature Substantia Nigra‐Like Structures with Therapeutic Effects on Parkinsonian Rats. Adv. Sci. 6, 1901822.
  7. Wang Y, Zhang M, Li Z, Yue J, Xu M, Zhang Y, Yung KKL, Li R (2019) Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells. Chemosphere 218, 577–588.
  8. Zhang M, Li Z, Xu M, Yue J, Cai Z, Yung KKL, Li R (2019) Pollution characteristics, source apportionment and health risks assessment of fine particulate matter during a typical winter and summer time period in urban Taiyuan, China. Hum. Ecol. Risk Assess.
  9. Zhang SQ, Yung KKL, Chung SK, Chung SMS (2018) Aldo-keto reductases-mediated cytotoxicity of 2-deoxyglucose: A novel anticancer mechanism. Cancer Sci. 109, 1970–1980.
  10. Zhang SQ, Lin KL, Law CY, Liu B, Fu XQ, Tse WS, Wong SSM, Sze SCW, Yung KKL (2018) Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity. Cell Death Discov. 4, 48.
  11. Li R, Zhang M, Wang Y, Yung KKL, Su R, Li Z, Zhao L, Dong C, Cai Z (2018) Effects of sub-chronic exposure to atmospheric PM2.5 on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in the livers of rats. Toxicol. Res. (Camb). 7, 271–282.

SELECTED PATENTS

  1. Yang, W.G., Wong, Y., Ng, O.T.W., Li, H.W. Yung, K.K.L., Kwong, D.W.J., Wong, R.M.S, “Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation” U.S. Patent 13/447,127, April 13, 2012.

  2.  Yang, W.G., Wong, Y., Ng, O.T.W., Li, H.W. Yung, K.K.L., Kwong, D.W.J., Wong, R.M.S, “β淀粉样肽的成像及β淀粉样肽的聚集的抑制” China Patent 201210119357.2, April 20, 2012.

  3. Yung, K.K.L., Li, H. W., Lui, N. P., Ho, S. L., Tsui, Y. P., Chan., Y. S., Shum, K. Y., & Tsang E. S. C., “Method of Extracting Neural Stem Cells Using Nanoparticles,” U.S. Patent 13/834,750, March 15, 2013.

  4.  Yung, K.K.L., Li, H. W., Lui, N. P., Ho, S. L., Tsui, Y. P., Chan., Y. S., Shum, K. Y., & Tsang E.S.C., “Method of Extracting Neural Stem Cells Using Nanoparticles,” PCT Patent WO 2014/075629 A1, November 15, 2013.

  5. Yang, W.G., Wong, Y., Ng, O.T.W., Li, H.W. Yung, K.K.L., Kwong, D.W.J., Wong, R.M.S, “Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation” U.S. Patent 14/231,715, March 31, 2014.

  6. Yang, W.G., Wong, Y., Ng, O.T.W., Li, H.W. Yung, K.K.L., Kwong, D.W.J., Wong, R.M.S, “Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation” U.S. Patent 14/231,724, March 31, 2014.

  7. Yung, K.K.L., Li, H. W., Lui, N. P., Ho, S. L., Tsui, Y. P., Chan., Y. S., Shum, K. Y., & Tsang E.S.C., “Method of Extracting Neural Stem Cells Using Nanoparticles,” EP Patent 13855417.5, March 24, 2015.

  8. Yung, K.K.L., Huang, Z.F., Zhang, S.Q. “Biocompatible Sculptured Extracel

SELECTED AWARDS

The Gold Medal in the Surgery Category and the Award for High Scientific and Technological Level of the Invention for “the autologous neural stem cell harvest technologies” in the 44th Geneva International Exhibition of Inventions (2016).

Email: kklyung@hkbu.edu.hk
Office: RRS 819
Office Tel: (+852) 3411 7060