PROF. YUNG, Ken Kin Lam (翁建霖)

Professor and Associate Head
EDUCATION

D.Phil. (Oxford)
M.Phil. (HKU)
B.Sc. (Hons.) (HKBU)

CURRENT RESEARCH INTERESTS

  • Neurobiology of receptors and neurological diseases
  • Neurotoxicology
  • Neuropharmacology

SELECTED PUBLICATIONS

  1. E.K.Y. Chung, L.W. Chen, Y.S. Chan and K.K.L. Yung, “Down regulations of glial glutamate transporters after dopamine denervation in the striatum of six-hydroxydopamine-lesioned rats”, J. Comp. Neurol. (In press, 2008).
  2. Y.C. Tse, C.H., Lai, S.K. Lai, J.X. Liu, K.K.L. Yung, D.K.Y. Shum and Y.S. Chan, “Developmental expression of NMDA and AMPA receptor subunits in vestibular nuclear neurons that encode gravity-related horizontal orientations”, J. Comp. Neurol. 508, 343-64 (2008).
  3. L.W. Chen, Y.Q Wang., G.L. Bian, L.C Wei and K.K.L.Yung, “Neurokinin-3 peptide instead of neurokinin-1 synergistically exacerbates kainic acid-inducing degeneration of neurons in the substantia nigra of mice”, J. Neurochem. 105, 203-216 (2008).
  4. L. Chen, K.K.L. Yung and W.H. Yung, “Neurotensin selectively facilitates glutamatergic transmission in globus pallidus”, Neuroscience 141, 1871-1878 (2006).
  5. S.K. Lai, C.H. Lai, K.K.L. Yung, D.K. Shum and Y.S. Chan, “Maturation of otolith-related brainstem neurons in the detection of vertical linear acceleration in rats”, Eur. J. Neurosci. 23: 2431-2446 (2006).
  6. W.K. Lau, W.H. Yung, Y.S. Chan and K.K.L. Yung, “Developmental assembly of GABA receptors in the rat substantia nigra”, Basal Ganglia VIII, pp. 229-240. Springer, New York (2005).
  7. L.W. Chen, K.K.L. Yung and Y.S. Chan, “Reactive astrocytes as potential manipulation targets in novel cell replacement therapy of Parkinson’s disease”, Curr. Drug Targets 6: 821-833 (2005).
  8. R.W.C. Lam, Y.S. Chan and K.K.L. Yung, “Differential localization of metabotropic glutamate receptors 1α and 2/3 in the rat striatum during early postnatal development”, Neuroembryology 3: 26-41 (2004-05).
  9. L. Chen, K. K. L. Yung, and W. H. Yung, “Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptor”, Neuroscience 125: 853-859 (2004).
  10. L. W. Chen, H. J. Hu, H. L. Liu, K. K. L. Yung, and Y. S. Chan, “Identification of brain-derived neurotrophic factor in nestin-expressing astroglial cells in the neostriatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice”, Neuroscience 126: 941-953 (2004).
  11. L. W. Chen, K. K. L. Yung, and Y. S. Chan, “Neurokinin peptides and neurokinin receptors as potential therapeutic intervention targets of basal ganglia in the prevention and treatment of Parkinson’s disease”, Current Drug Targets 5: 197-206 (2004) (review).
  12. H. J. Hu, L. W. Chen, K. K. L. Yung, and Y. S. Chan, “Differential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of rats”, Neurosci. Res. 49: 281-288 (2004).
  13. C. H. Lai, Y. C. Tse, D. K. Y. Shum, K. K. L. Yung, and Y. S. Chan, “Fos expression in otolith-related brainstem neurons of postnatal rats following off-vertical axis rotation”, Journal of Comparative Neurology 470: 282-296 (2004).
  14. S. K. Lai, T. K. Y. Ng, W. K. Lau, M. S. Yang, C. K. C. Wong, Y. S. Chan, and K. K. L. Yung, “Selective knockdown of gene expression of N-methyl-D-aspartate receptor one ameliorates parkinsonian motor symptom in 6-hydroxydopamine-lesioned rats”, Neurochem. Int. 45: 11-22 (2004).
  15. W. K. Lau, P. W. Lui, C. K. C. Wong, Y. S. Chan, and K. K. L. Yung, “Differential expression of N-methyl-D-aspartate receptor subunit messenger ribonucleic acids and immunoreactivity in the rat neostriatum during postnatal development”, Neurochem. Int. 43: 47-65 (2003).
  16. P. W. Lui, K. C. Suen, Y. S. Chan, W. H. Yung, and K. K. L. Yung, “Striatal neurons but not nigral dopaminergic neurons in neonatal primary cell culture express endogenous functional N-methyl-D-aspartate receptors”, Brain Res. Mol. Brain Res. 120: 9-21 (2003).
  17. Y. S. Chan, L. W. Chen, C. H. Lai, D. K. Shum, K. K. L. Yung, and F. X. Zhang, “Receptors of glutamate and neurotrophin in vestibular neuronal functions”, J. Biomed. Sci. 10: 577-587 (2003) (review).
  18. W. S. Chan, C. W. Yeung, E. K. Y. Chung, W. K. Lau, Y. S. Chan, and K. K. L. Yung, “Differential expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate glutamate receptors in the rat striatum during postnatal development”, Neurosignals 12: 302-309 (2003) (Invited).

CONTACT DETAILS

Email: kklyung@hkbu.edu.hk
Office: T1103
Office Tel: (+852) 3411 7060